GALUEGA FUA SAʻOLE

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Masani tino metabolism
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Faʻaleagaina o le ea
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Lafoaia o le Ultraviolet
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Faʻaleagaina mamafa uʻamea
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Faʻaleagaina o vailaʻau
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Faʻaleagaina o vailaʻau

 

 

FUA FUA MA MAʻi

 

E masani lava, e manaʻomia radicals fua mo tino, ae o soʻona saoloto radicals mafai mafua ai le le paleni o le tino galue, ona taitai atu ai i le oxidative popole fesuisuiai i le tele o faamai (literities faailoa mai saoloto radicals o le mafuaʻaga o eseese maʻi).

 

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FAʻAALIGA

 

E le mafai ona faʻagaioia o tatou tino e aunoa ma le okesene, ma o le taimi e faʻateleina ai le tele o vailaʻau fua, o le tino o loʻo faʻamamaina le oxidative o le a mafua ai ona le manuia le toe faʻaleleia o le tino i le aveʻesea o le tele o mea. I tulaga faʻapitoa, e manaʻomia e le tino le toe faʻatumuina o ni vailaʻau oona i vitro e aveʻesea ai le tele o radicals maua fua.

 

FAALAUTELEGA O TUSI FAITAU

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L-ERGOTHIONEINE –O SE ITUAIGA FOU O LE FAʻALELENEGA FAʻALELEIA

 

EGT o se natura chiral amino-acid antioxidant biosynthesized i nisi siama ma fungus. O se taua bioactive tuʻufaʻatasi lea na faʻaaogaina o se radical scavenger, o se ultraviolet ray filter, o se regulator o oxidation-faʻaititia o faʻaititia-faʻaititia sela ma bioenergetics sela, ma se cytoprotector physiological, ma isi
L-Ergothioneine (EGT, ERGO, CAS: 497-30-3), e faʻaigoa foi o (S) -α-Carboxy-2,3-dihydro-N, N, N-trimethyl-2-thioxo-1H-imidazole- 4-ethanaminium masima totonu, na muaʻi aumai i le ergot e Tanret C i le 1909, ona maua ai foi lea i toto o manu. Pure EGT o le paʻepaʻe paʻepaʻe, e maitauina ile vai, (faʻasaʻoina 0.9mol / L ile potu vevela). Autoxidation e le mafai ona tupu i tulaga ole pH paʻu poʻo le fofo malosi. EGT mafai ona i ai i le lua isomer foliga - se thiol foliga ma se thione pepa, pei ona faʻaalia i lalo:

 

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FAʻAALIGA

Ma le lelei o tele-gaioiga, EGT tu matilatila i le tele o isi antioxidants.

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tulaga lelei

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Faatasi ai ma le lelei o tele-gaioiga, EGT tu i fafo faʻatasi ma le tele o isi antioxidantsLelei (faʻatusatusa i le glutathione, cysteine ​​ma isi):
——EGT e faigofie ona faʻaputuputu i sela ma o le faʻasologa e sili atu le mautu nai lo isi antioxidants.
——EGT e sili atu le aoga i le faaitiitia sela maliu e mafua mai pyrogallol.
——EGT masani lava ona faʻamamaina le ROS e puipuia ai le faʻamaʻaina o le tino, aʻo le glutathione ma isi e faʻamamaina le saolotoga, o isi ia antioxidants scavenge oloa oxidation.

FAʻASOAGA O FAʻAFETAI

Tali: EGT o le sili gaioiga scavenger o saoloto radicals pe a faʻatusatusa i le masani antioxidants pei GSH, uric acid ma trolox. Ae maise lava, o le maualuga maualuga antioxidant gafatia faʻaalia e EGT vs. peroxyl radicals na mafua ai le 25% maualuga atu nai lo le tau na maua mai i le faʻasino igoa antioxidant trolox. O le mafai gafatia o EGT agai hydroxyl radicals sa 60% maualuga, pe a faʻatusatusa i uric acid, lea e fai ma sui o le faasinomaga antioxidant vs. hydroxyl radicals. I le iuga, EGT faʻaalia le maualuga gaioiga faʻamalosiʻau faʻagaioia foi i le peroxynitrite, ma le faʻamaluluina gafatia 10% maualuga atu nai lo lena o uric acid.

 

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O ISI FUAFUAGA

 

E iai foi aʻafiaga a le EGT i le faʻatonutonuina o le malosiʻesea iniselular,
faaleleia le puipuiga malu,
faaleleia le saoasaoa tulaga o sperm,
puipuia le ate mai manuʻa,
taofia o le afaina,
neurodegeneration,
atinae faaletonu ma cataract.

 

 

MANAʻOGA O ATINAʻE

① O LE EGT NA MAFAI ONA MAUA I FUAFUAGA MA MANU

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② FAATONUGA

5-10mg ile iunite mo se tagata matua ma 2-3 iunite faʻaauau faʻaaluina e taua i au meaʻai i aso uma.

Punavai: Li Yiqun, Zhou Nianbo. Biology Function ma Talosaga a le EGT [J]. Meaʻai Inisinia, 2010 ile9 3 26) : 28-XNUMX.

O loʻo lisiina atu i lalo suʻega:

Tamaiti (3-11 tausaga) 0l XNUMX mg / aso
Autalavou (11-21 tausaga) ≤30 mg / aso
Matutua (21-80 tausaga) ≤30 mg / aso

Faʻaaliga : 1. Totogi mo tamaiti ma tagata matutua (3 -80 tausaga le matua

           2.Use mo fafine maʻito pe lactating e le fautuaina.

Faʻamatalaga puna: Tetrahedron pe a apalai mo US NDI

Faʻamatalaga fautuaina: 10.5mg / g mo OXIS's ADI (Taliaina i Aso Taitasi Intake).

 

N FAASINO

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FAAILOGA & APPLICATION

(1) FAAALIGA

I le taimi nei, e tolu metotia mo le gaosiga o le EGT: synthes synthes, faalenatura aveese mai le bio (e tele lava mai le pulou, meaola o manu ma le tosoina o le toto), ma le biosynthesis auala.

Faʻatusatusaga o le EGT Extraction Metotia

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(2) TALOSAGA

EGT e lautele faʻaoga i mea teuteu, taumafa galue, vailaʻau, vailaʻau, biomedisin, ma isi.

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(3) O ISI TUPE MAUA

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Mataupu